This document is a comprehensive resource for best and promising practices for tobacco prevention and control for the LGBT community. Seeking to close the tobacco disparity gap (LGBT people smoke at rates from 35% to almost 200% higher than the general population), the authors adapted the World Health Organization’s best practices model, MPOWER, and added two letters to address key challenges faced by LGBT people, creating MPOWERED. The strategies include: Monitor the epidemic, including diverse and marginalized populations such as the LGBT community; Protect LGBT people from tobacco smoke; Offer help that is LGBT-culturally appropriate; Warn the LGBT community that they are targeted by tobacco industry media and marketing campaigns, and provide LGBT-specific media campaigns to counter the tobacco epidemic; Enforce the banning of tobacco industry promotions and sponsorships in LGBT community activities and events; Raise taxes on tobacco products and use the revenue for cessation programs designed specifically for LGBT people; Evaluate programs to determine which work best In terms of outcomes and cost; and Diversify the tobacco control movement to be inclusive of race, ethnicity, youth, sexual orientation and gender identity. Target audience for this document includes policy makers, grant makes and grant applicants target audience projects and policies.